Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1

Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential associated to dormancy. Here we identify the cell surface receptor neogenin-1 as specifically expressed in dormant HSCs. Loss of neogenin-1 initially leads to increased HSC expansion but subsequently to loss of self-r...

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Publicado no:Nat Commun
Main Authors: Renders, Simon, Svendsen, Arthur Flohr, Panten, Jasper, Rama, Nicolas, Maryanovich, Maria, Sommerkamp, Pia, Ladel, Luisa, Redavid, Anna Rita, Gibert, Benjamin, Lazare, Seka, Ducarouge, Benjamin, Schönberger, Katharina, Narr, Andreas, Tourbez, Manon, Dethmers-Ausema, Bertien, Zwart, Erik, Hotz-Wagenblatt, Agnes, Zhang, Dachuan, Korn, Claudia, Zeisberger, Petra, Przybylla, Adriana, Sohn, Markus, Mendez-Ferrer, Simon, Heikenwälder, Mathias, Brune, Maik, Klimmeck, Daniel, Bystrykh, Leonid, Frenette, Paul S., Mehlen, Patrick, de Haan, Gerald, Cabezas-Wallscheid, Nina, Trumpp, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840807/
https://ncbi.nlm.nih.gov/pubmed/33504783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20801-0
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