Plasmonic nanoparticle amyloid corona for screening Aβ oligomeric aggregate-degrading drugs

The generation of toxic amyloid β (Aβ) oligomers is a central feature of the onset and progression of Alzheimer’s disease (AD). Drug discoveries for Aβ oligomer degradation have been hampered by the difficulty of Aβ oligomer purification and a lack of screening tools. Here, we report a plasmonic nan...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Lee, Dongtak, Park, Dongsung, Kim, Insu, Lee, Sang Won, Lee, Wonseok, Hwang, Kyo Seon, Lee, Jeong Hoon, Lee, Gyudo, Yoon, Dae Sung
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840768/
https://ncbi.nlm.nih.gov/pubmed/33504788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20611-4
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