Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion

Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation. Here, we show that ICOSL is heavily downmodulated dur...

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Veröffentlicht in:eLife
Hauptverfasser: Angulo, Guillem, Zeleznjak, Jelena, Martínez-Vicente, Pablo, Puñet-Ortiz, Joan, Hengel, Hartmut, Messerle, Martin, Oxenius, Annette, Jonjic, Stipan, Krmpotić, Astrid, Engel, Pablo, Angulo, Ana
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2021
Schlagworte:
Immunology and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840182/
https://ncbi.nlm.nih.gov/pubmed/33459589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59350
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