Methotrexate attenuates vascular inflammation through an adenosine-microRNA-dependent pathway

Endothelial cell (EC) activation is an early hallmark in the pathogenesis of chronic vascular diseases. MicroRNA-181b (Mir181b) is an important anti-inflammatory mediator in the vascular endothelium affecting endotoxemia, atherosclerosis, and insulin resistance. Herein, we identify that the drug met...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Yang, Dafeng, Haemmig, Stefan, Zhou, Haoyang, Pérez-Cremades, Daniel, Sun, Xinghui, Chen, Lei, Li, Jie, Haneo-Mejia, Jorge, Yang, Tianlun, Hollan, Ivana, Feinberg, Mark W
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2021
Assuntos:
Immunology and Inflammation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840179/
https://ncbi.nlm.nih.gov/pubmed/33416495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58064
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