Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation

The p53/p21 pathway is activated in response to cell stress. However, its role in acute lung injury has not been elucidated. Acute lung injury is associated with disruption of the alveolo-capillary barrier leading to acute respiratory distress syndrome (ARDS). Mechanical ventilation may be necessary...

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Bibliographische Detailangaben
Veröffentlicht in:Transl Res
Hauptverfasser: Blázquez-Prieto, Jorge, Huidobro, Covadonga, López-Alonso, Inés, Amado-Rodriguez, Laura, Martín-Vicente, Paula, López-Martínez, Cecilia, Crespo, Irene, Pantoja, Cristina, Fernandez-Marcos, Pablo J, Serrano, Manuel, Sznajder, Jacob I, Albaiceta, Guillermo M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Inc. 2021
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7838583/
https://ncbi.nlm.nih.gov/pubmed/33515780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2021.01.008
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