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Hemodynamic Effects of a Soluble Guanylate Cyclase Stimulator, Riociguat, and an Activator, Cinaciguat, During NO-Modulation in Healthy Pigs

Cardiovascular diseases are often characterized by dysfunctional endothelium. To compensate for the related lack of nitric oxide (NO), a class of soluble guanylate cyclase (sGC) stimulators and activators have been developed with the purpose of acting downstream of NO in the NO-sGC-cGMP cascade. The...

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Publicado en:J Cardiovasc Pharmacol Ther
Autores principales: Næsheim, Torvind, How, Ole-Jakob, Myrmel, Truls
Formato: Artigo
Lenguaje:Inglês
Publicado: SAGE Publications 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7838342/
https://ncbi.nlm.nih.gov/pubmed/32662299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1074248420940897
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