Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry

Symmetrical protein complexes are ubiquitous in biology. Many have been re-engineered for chemical and medical applications. Viral capsids and their assembly are frequent platforms for these investigations. A means to create asymmetric capsids may expand applications. Here, starting with homodimeric...

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Udgivet i:Nat Commun
Main Authors: Zhao, Zhongchao, Wang, Joseph Che-Yen, Zhang, Mi, Lyktey, Nicholas A., Jarrold, Martin F., Jacobson, Stephen C., Zlotnick, Adam
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7838286/
https://ncbi.nlm.nih.gov/pubmed/33500404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20862-1
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