The Influence of NAT2 Genotypes on Isoniazid Plasma Concentration of Pulmonary Tuberculosis Patients in Southern Thailand

BACKGROUND: Isoniazid (INH) is metabolized by polymorphic N-acetyltransferase 2 (NAT2) enzyme, which noticeably alters INH plasma concentration. We aimed to determine the distribution of NAT2 genotype in Thai tuberculosis (TB) patients and correlate their genotype with plasma INH concentrations. MET...

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Detalhes bibliográficos
Publicado no:Tuberc Respir Dis (Seoul)
Main Authors: Ungcharoen, Usanee, Sriplung, Hutcha, Mahasirimongkol, Surakameth, Chusri, Saranyou, Wichukchinda, Nuanjun, Mokmued, Phongpan, Wattanapokayakit, Sukanya, Chongsuvivatwong, Virasakdi
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Academy of Tuberculosis and Respiratory Diseases 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7837378/
https://ncbi.nlm.nih.gov/pubmed/33138342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4046/trd.2020.0068
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