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F-domain valency determines outcome of signaling through the angiopoietin pathway
Angiopoietin 1 and 2 (Ang1 and Ang2) modulate angiogenesis and vascular homeostasis through engagement of their very similar F-domain modules with the Tie2 receptor tyrosine kinase on endothelial cells. Despite this similarity in the underlying receptor binding interaction, the two angiopoietins hav...
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| 出版年: | bioRxiv |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7836102/ https://ncbi.nlm.nih.gov/pubmed/33501432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.09.19.304188 |
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