Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

Tumour necrosis factor (TNF) is a trimeric protein which signals through two membrane receptors, TNFR1 and TNFR2. Previously, we identified small molecules that inhibit human TNF by stabilising a distorted trimer and reduce the number of receptors bound to TNF from three to two. Here we present a bi...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: McMillan, David, Martinez-Fleites, Carlos, Porter, John, Fox, David, Davis, Rachel, Mori, Prashant, Ceska, Tom, Carrington, Bruce, Lawson, Alastair, Bourne, Tim, O’Connell, James
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835368/
https://ncbi.nlm.nih.gov/pubmed/33495441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20828-3
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