ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response

ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 susceptibility or severity, and the role of direct viral infection in brain cells remains obscure. We tested the neurotropism o...

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Bibliographic Details
Published in:Cell Stem Cell
Main Authors: Wang, Cheng, Zhang, Mingzi, Garcia, Gustavo, Tian, E., Cui, Qi, Chen, Xianwei, Sun, Guihua, Wang, Jinhui, Arumugaswami, Vaithilingaraja, Shi, Yanhong
Format: Artigo
Language:Inglês
Published: Elsevier Inc. 2021
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Short Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7832490/
https://ncbi.nlm.nih.gov/pubmed/33450186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.12.018
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