A Reproducible and Scalable Process for Manufacturing a Pfs48/45 Based Plasmodium falciparum Transmission-Blocking Vaccine

The cysteine-rich Pfs48/45 protein, a Plasmodium falciparum sexual stage surface protein, has been advancing as a candidate antigen for a transmission-blocking vaccine (TBV) for malaria. However, Pfs48/45 contains multiple disulfide bonds, that are critical for proper folding and induction of transm...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Singh, Susheel K., Plieskatt, Jordan, Chourasia, Bishwanath K., Fabra-García, Amanda, Garcia-Senosiain, Asier, Singh, Vandana, Bengtsson, Karin Lövgren, Reimer, Jenny M., Sauerwein, Robert, Jore, Matthijs M., Theisen, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7832176/
https://ncbi.nlm.nih.gov/pubmed/33505395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.606266
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