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Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing

Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak antibacterial activity produced by Streptomyces clavuligerus (S. clavuligerus). CA is typically co-formulated with broad-spectrum β‑lactam antibiotics such as amoxicillin, conferring them high potential to treat disease...

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Detalhes bibliográficos
Publicado no:Antibiotics (Basel)
Main Authors: López-Agudelo, Víctor A., Gómez-Ríos, David, Ramirez-Malule, Howard
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830376/
https://ncbi.nlm.nih.gov/pubmed/33477401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics10010084
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