Chimeric Porcine Deltacoronaviruses with Sparrow Coronavirus Spike Protein or the Receptor-Binding Domain Infect Pigs but Lose Virulence and Intestinal Tropism

Porcine deltacoronavirus (PDCoV) strain OH-FD22 infects poultry and shares high nucleotide identity with sparrow-origin deltacoronaviruses (SpDCoV) ISU73347 and HKU17 strains. We hypothesized that the spike (S) protein or receptor-binding domain (RBD) from these SpDCoVs would alter the host and tiss...

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Veröffentlicht in:Viruses
Hauptverfasser: Niu, Xiaoyu, Hou, Yixuan J., Jung, Kwonil, Kong, Fanzhi, Saif, Linda J., Wang, Qiuhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7829776/
https://ncbi.nlm.nih.gov/pubmed/33477379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v13010122
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