Exome sequencing links CEP120 mutation to maternally derived aneuploid conception risk

STUDY QUESTION: What are the genetic factors that increase the risk of aneuploid egg production? SUMMARY ANSWER: A non-synonymous variant rs2303720 within centrosomal protein 120 (CEP120) disrupts female meiosis in vitro in mouse. WHAT IS KNOWN ALREADY: The production of aneuploid eggs, with an adva...

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Vydáno v:Hum Reprod
Hlavní autoři: Tyc, Katarzyna M, El Yakoubi, Warif, Bag, Aishee, Landis, Jessica, Zhan, Yiping, Treff, Nathan R, Scott, Richard T, Tao, Xin, Schindler, Karen, Xing, Jinchuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7828473/
https://ncbi.nlm.nih.gov/pubmed/32772081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/deaa148
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