Milk fat globule EGF factor 8 restores mitochondrial function via integrin‐medicated activation of the FAK‐STAT3 signaling pathway in acute pancreatitis

ABSTRACT: Acute pancreatitis (AP) remains a significant clinical challenge. Mitochondrial dysfunction contributes significantly to the pathogenesis of AP. Milk fat globule EGF factor 8 (MFG‐E8) is an opsonizing protein, which has many biological functions via binding to αvβ3/5 integrins. Ligand‐depe...

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Detalhes bibliográficos
Publicado no:Clin Transl Med
Main Authors: Ren, Yifan, Liu, Wuming, zhang, Lin, Zhang, Jia, Bi, Jianbin, Wang, Tao, Wang, Mengzhou, Du, Zhaoqing, Wang, Yawen, Wu, Zheng, Lv, Yi, Meng, Lingzhong, Wu, Rongqian
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7828261/
https://ncbi.nlm.nih.gov/pubmed/33634976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.295
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