Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death

The hippocampal cell death that follows kainic acid (KA)-induced seizures is associated with blood–brain barrier (BBB) leakage and oxidative stress. Lipocalin-2 (LCN2) is an iron-trafficking protein which contributes to both oxidative stress and inflammation. However, LCN2′s role in KA-induced hippo...

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Veröffentlicht in:Antioxidants (Basel)
Hauptverfasser: Shin, Hyun Joo, Jeong, Eun Ae, Lee, Jong Youl, An, Hyeong Seok, Jang, Hye Min, Ahn, Yu Jeong, Lee, Jaewoong, Kim, Kyung Eun, Roh, Gu Seob
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7828212/
https://ncbi.nlm.nih.gov/pubmed/33445746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10010100
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