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Counteracting Effects of Glutathione on the Glutamate-Driven Excitation/Inhibition Imbalance in First-Episode Schizophrenia: A 7T MRS and Dynamic Causal Modeling Study

Oxidative stress plays a key role in the pathophysiology of schizophrenia. While free radicals produced by glutamatergic excess and oxidative metabolism have damaging effects on brain tissue, antioxidants such as glutathione (GSH) counteract these effects. The interaction between glutamate (GLU) and...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Limongi, Roberto, Jeon, Peter, Théberge, Jean, Palaniyappan, Lena
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7828075/
https://ncbi.nlm.nih.gov/pubmed/33430154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10010075
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