Targeting alternative splicing by RNAi: from the differential impact on splice variants to triggering artificial pre-mRNA splicing

Alternative splicing generates multiple transcript and protein isoforms from a single gene and controls transcript intracellular localization and stability by coupling to mRNA export and nonsense-mediated mRNA decay (NMD). RNA interference (RNAi) is a potent mechanism to modulate gene expression. Ho...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Fuchs, Armin, Riegler, Stefan, Ayatollahi, Zahra, Cavallari, Nicola, Giono, Luciana E, Nimeth, Barbara A, Mutanwad, Krishna V, Schweighofer, Alois, Lucyshyn, Doris, Barta, Andrea, Petrillo, Ezequiel, Kalyna, Maria
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2021
Onderwerpen:
RNA and RNA-protein complexes
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826280/
https://ncbi.nlm.nih.gov/pubmed/33406240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1260
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