Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization

The prebiotic synthesis of ribonucleotides is likely to have been accompanied by the synthesis of noncanonical nucleotides including the threo-nucleotide building blocks of TNA. Here, we examine the ability of activated threo-nucleotides to participate in nonenzymatic template-directed polymerizatio...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Zhang, Wen, Kim, Seohyun Chris, Tam, Chun Pong, Lelyveld, Victor S, Bala, Saikat, Chaput, John C, Szostak, Jack W
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Chemical Biology and Nucleic Acid Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826252/
https://ncbi.nlm.nih.gov/pubmed/33347562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1215
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