Combination of Cisplatin and Irradiation Induces Immunogenic Cell Death and Potentiates Postirradiation Anti–PD-1 Treatment Efficacy in Urothelial Carcinoma

The therapeutic benefit of immune checkpoint inhibitor monotherapy is limited to a subset of patients in urothelial carcinoma (UC). Previous studies showed the immunogenicity of cisplatin and irradiation. Here, we investigated whether chemoradiotherapy (CRT), a combination of cisplatin and irradiati...

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Pubblicato in:Int J Mol Sci
Autori principali: Fukushima, Hiroshi, Yoshida, Soichiro, Kijima, Toshiki, Nakamura, Yuki, Fukuda, Shohei, Uehara, Sho, Yasuda, Yosuke, Tanaka, Hajime, Yokoyama, Minato, Matsuoka, Yoh, Fujii, Yasuhisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7825793/
https://ncbi.nlm.nih.gov/pubmed/33430352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020535
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