Mapping the SARS-CoV-2–Host Protein–Protein Interactome by Affinity Purification Mass Spectrometry and Proximity-Dependent Biotin Labeling: A Rational and Straightforward Route to Discover Host-Directed Anti-SARS-CoV-2 Therapeutics

Protein–protein interactions (PPIs) are the vital engine of cellular machinery. After virus entry in host cells the global organization of the viral life cycle is strongly regulated by the formation of virus-host protein interactions. With the advent of high-throughput -omics platforms, the mirage t...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Terracciano, Rosa, Preianò, Mariaimmacolata, Fregola, Annalisa, Pelaia, Corrado, Montalcini, Tiziana, Savino, Rocco
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7825748/
https://ncbi.nlm.nih.gov/pubmed/33430309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020532
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