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Enantioselective Synthesis of (+)-Hippolide J and Reevaluation of Antifungal Activity

A synthesis of the reported antifungal agent (+)-hippolide J is presented. The rapid assembly of the natural product was enabled through implementation of an enantioselective isomerization/[2 + 2]-cycloaddition sequence. Due to the simplicity of the route, >100 mg of the natural product were prep...

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Publicado en:Org Lett
Autores principales: Guo, Renyu, Beattie, Sarah R., Krysan, Damian J., Brown, M. Kevin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7824975/
https://ncbi.nlm.nih.gov/pubmed/32969231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c02979
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