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Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function

Alternative splicing generates multiple distinct isoforms that increase transcriptome and proteome diversity. There are seven sirtuin genes in humans, each consists of multiple exons that are likely to undergo alternative splicing. Our aim was to characterize the effect of alternative splicing on th...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Zhang, Xiaomin, Ameer, Fathima S., Azhar, Gohar, Wei, Jeanne Y.
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7824890/
https://ncbi.nlm.nih.gov/pubmed/33418837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020473
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