Alcohol-and-HIV-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion in Vitro and in Liver-Humanized Mice

SIMPLE SUMMARY: Consumption of alcohol increases liver damage in HIV people; however, the mechanisms remain elusive. By utilizing alcohol (ethanol) exposed HIV-infected human hepatocytes liver cells and ethanol-fed liver humanized mouse model (immunodeficient mice livers harbor human hepatocytes), w...

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Publicat a:Biology (Basel)
Autors principals: Dagur, Raghubendra Singh, New-Aaron, Moses, Ganesan, Murali, Wang, Weimin, Romanova, Svetlana, Kidambi, Srivatsan, Kharbanda, Kusum K., Poluektova, Larisa Y., Osna, Natalia A.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7824801/
https://ncbi.nlm.nih.gov/pubmed/33466299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology10010029
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