Tofacitinib Ameliorates Lipopolysaccharide-Induced Acute Kidney Injury by Blocking the JAK-STAT1/STAT3 Signaling Pathway

Septic acute kidney injury (AKI) is the most common AKI syndrome in the intensive care unit (ICU), and it accounts for approximately half of AKI cases. Tofacitinib (TOFA) is a pan-Janus kinase (JAK) inhibitor that exhibits potent anti-inflammatory activity in rheumatoid arthritis. However, no study...

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Publicat a:Biomed Res Int
Autors principals: Yun, Yang, Chen, Jingyu, Wang, Xuejiao, Li, Yingzhuo, Hu, Zhifan, Yang, Pingting, Qin, Ling
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822662/
https://ncbi.nlm.nih.gov/pubmed/33511217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8877056
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