Analogues of 2′-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase

A series of C4-substituted tertiary nitrogen-bearing 2′-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. Majority of the 2′-hydroxychalcone analogues displayed a better inhibition against acetylcholinesterase (AChE) than butyrylcholinester...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Sukumaran, Sri Devi, Nasir, Shah Bakhtiar, Tee, Jia Ti, Buckle, Michael J. C., Othman, Rozana, Rahman, Noorsaadah Abd., Lee, Vannajan Sanghiran, Bukhari, Syed Nasir Abbas, Chee, Chin Fei
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822063/
https://ncbi.nlm.nih.gov/pubmed/33243025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1847100
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