Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives

INTRODUCTION: Studies examining the effect of polygenic risk scores (PRS) for Alzheimer's disease (AD) and apolipoprotein E (APOE) genotype on incident dementia in very old individuals are lacking. METHODS: A population‐based sample of 2052 individuals ages 70 to 111, from Sweden, was followed...

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Bibliographic Details
Published in:Alzheimers Dement (Amst)
Main Authors: Najar, Jenna, van der Lee, Sven J., Joas, Erik, Wetterberg, Hanna, Hardy, John, Guerreiro, Rita, Bras, Jose, Waern, Margda, Kern, Silke, Zetterberg, Henrik, Blennow, Kaj, Skoog, Ingmar, Zettergren, Anna
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821873/
https://ncbi.nlm.nih.gov/pubmed/33532541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dad2.12142
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