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uKIN combines new and prior information with guided network propagation to accurately identify disease genes
Protein interaction networks provide a powerful framework for identifying genes causal for complex genetic diseases. Here we introduce a general framework, uKIN, that uses prior knowledge of disease associated genes to guide, within known protein-protein interaction networks, random walks that are i...
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| Published in: | Cell Syst |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7821437/ https://ncbi.nlm.nih.gov/pubmed/32684276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.05.008 |
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