Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome

Brugada syndrome (BrS) is an inherited arrhythmogenic disease that may lead to sudden cardiac death in young adults with structurally normal hearts. No pharmacological therapy is available for BrS patients. This situation highlights the urgent need to overcome current difficulties by developing nove...

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Bibliographische Detailangaben
Veröffentlicht in:Front Physiol
Hauptverfasser: Di Mauro, Vittoria, Ceriotti, Paola, Lodola, Francesco, Salvarani, Nicolò, Modica, Jessica, Bang, Marie-Louise, Mazzanti, Andrea, Napolitano, Carlo, Priori, Silvia G., Catalucci, Daniele
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821386/
https://ncbi.nlm.nih.gov/pubmed/33488405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.616819
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