Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

Thousands of human small and alternative open reading frames (smORFs and alt-ORFs, respectively) have recently been annotated. Many alt-ORFs are co-encoded with canonical proteins in multicistronic configurations, but few of their functions are known. Here, we report the detection of alt-RPL36, a pr...

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Publicado no:Nat Commun
Main Authors: Cao, Xiongwen, Khitun, Alexandra, Luo, Yang, Na, Zhenkun, Phoodokmai, Thitima, Sappakhaw, Khomkrit, Olatunji, Elizabeth, Uttamapinant, Chayasith, Slavoff, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820019/
https://ncbi.nlm.nih.gov/pubmed/33479206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20841-6
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