The number of osteoclasts in a biopsy specimen can predict the efficacy of neoadjuvant chemotherapy for primary osteosarcoma

Osteosarcoma is the most common primary malignant bone tumor, and its standard treatment is a combination of surgery and chemotherapy. A poor response to chemotherapy causes unfavorable oncological outcomes. We investigated the correlation between osteoclast differentiation in biopsy specimens and t...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Araki, Yoshihiro, Yamamoto, Norio, Hayashi, Katsuhiro, Takeuchi, Akihiko, Miwa, Shinji, Igarashi, Kentaro, Higuchi, Takashi, Abe, Kensaku, Taniguchi, Yuta, Yonezawa, Hirotaka, Morinaga, Sei, Asano, Yohei, Ikeda, Hiroko, Nojima, Takayuki, Tsuchiya, Hiroyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820005/
https://ncbi.nlm.nih.gov/pubmed/33479294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80504-w
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