Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers

BACKGROUND AND AIMS: Photochemical internalization (PCI) is a technology for inducing release of endocytosed antigens into the cell cytosol via a light-induced process. Preclinical experiments have shown that PCI improves MHC class I antigen presentation, resulting in strongly enhanced CD8+ T-cell r...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Otterhaug, Tone, Janetzki, Sylvia, Welters, Marij J. P., Håkerud, Monika, Nedberg, Anne Grete, Edwards, Victoria Tudor, Boekestijn, Sanne, Loof, Nikki M., Selbo, Pål Kristian, Olivecrona, Hans, van der Burg, Sjoerd H., Høgset, Anders
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819858/
https://ncbi.nlm.nih.gov/pubmed/33488576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.576756
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