Topical co‐administration of zoledronate with recombinant human bone morphogenetic protein-2 can induce and maintain bone formation in the bone marrow environment

BACKGROUND: Bone morphogenetic proteins (BMPs) induce osteogenesis in various environments. However, when BMPs are used alone in the bone marrow environment, the maintenance of new bone formation is difficult owing to vigorous bone resorption. This is because BMPs stimulate the differentiation of no...

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Pubblicato in:BMC Musculoskelet Disord
Autori principali: Ueyama, Hideki, Ohta, Yoichi, Imai, Yuuki, Suzuki, Akinobu, Sugama, Ryo, Minoda, Yukihide, Takaoka, Kunio, Nakamura, Hiroaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819170/
https://ncbi.nlm.nih.gov/pubmed/33472600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-021-03971-w
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