Topical co‐administration of zoledronate with recombinant human bone morphogenetic protein-2 can induce and maintain bone formation in the bone marrow environment

BACKGROUND: Bone morphogenetic proteins (BMPs) induce osteogenesis in various environments. However, when BMPs are used alone in the bone marrow environment, the maintenance of new bone formation is difficult owing to vigorous bone resorption. This is because BMPs stimulate the differentiation of no...

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Bibliographic Details
Published in:BMC Musculoskelet Disord
Main Authors: Ueyama, Hideki, Ohta, Yoichi, Imai, Yuuki, Suzuki, Akinobu, Sugama, Ryo, Minoda, Yukihide, Takaoka, Kunio, Nakamura, Hiroaki
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819170/
https://ncbi.nlm.nih.gov/pubmed/33472600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-021-03971-w
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