Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar‐Based Molecules that Target Bacterial Glucosyltransferase

We applied dynamic combinatorial chemistry (DCC) to find novel ligands of the bacterial virulence factor glucosyltransferase (GTF) 180. GTFs are the major producers of extracellular polysaccharides, which are important factors in the initiation and development of cariogenic dental biofilms. Followin...

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Udgivet i:ChemMedChem
Main Authors: Hartman, Alwin M., Jumde, Varsha R., Elgaher, Walid A. M., Te Poele, Evelien M., Dijkhuizen, Lubbert, Hirsch, Anna K. H.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Full Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818428/
https://ncbi.nlm.nih.gov/pubmed/32542998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000222
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