Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar‐Based Molecules that Target Bacterial Glucosyltransferase

We applied dynamic combinatorial chemistry (DCC) to find novel ligands of the bacterial virulence factor glucosyltransferase (GTF) 180. GTFs are the major producers of extracellular polysaccharides, which are important factors in the initiation and development of cariogenic dental biofilms. Followin...

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Pubblicato in:ChemMedChem
Autori principali: Hartman, Alwin M., Jumde, Varsha R., Elgaher, Walid A. M., Te Poele, Evelien M., Dijkhuizen, Lubbert, Hirsch, Anna K. H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818428/
https://ncbi.nlm.nih.gov/pubmed/32542998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000222
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