Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner

In inflamed joints, enhanced hyaluronic acid (HA) degradation is closely related to the pathogenesis of rheumatoid arthritis (RA). KIAA1199 has been identified as a hyaladherin that mediates the intracellular degradation of HA, but its extracellular function remains unclear. In this study, we found...

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Pubblicato in:Cell Death Dis
Autori principali: Zhang, Wei, Yin, Guoyu, Zhao, Heping, Ling, Hanzhi, Xie, Zhen, Xiao, Chipeng, Chen, Yan, Lin, Yufan, Jiang, Tao, Jin, Shengwei, Wang, Jianguang, Yang, Xinyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817834/
https://ncbi.nlm.nih.gov/pubmed/33473125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03393-5
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