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Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency

FOXA2 has been identified as an essential factor for pancreas development and emerging evidence supports an association between FOXA2 and diabetes. Although the role of FOXA2 during pancreatic development is well-studied in animal models, its role during human islet cell development remains unclear....

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Publicado en:Cell Death Dis
Main Authors: Elsayed, Ahmed K., Younis, Ihab, Ali, Gowher, Hussain, Khalid, Abdelalim, Essam M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817686/
https://ncbi.nlm.nih.gov/pubmed/33473118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03390-8
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