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Protein structural heterogeneity: A hypothesis for the basis of proteolytic recognition by the main protease of SARS-CoV and SARS-CoV-2
The main protease (M(pro)) of SARS-CoV and SARS-CoV-2 is a key enzyme in viral replication and a promising target for the development of antiviral therapeutics. The understanding of this protein is based on a number of observations derived from earlier x-ray structures, which mostly consider substra...
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| Publicado no: | Biochimie |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM).
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7817518/ https://ncbi.nlm.nih.gov/pubmed/33484784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2021.01.010 |
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