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Tregs self-organize into a computing ecosystem and implement a sophisticated optimization algorithm for mediating immune response
Regulatory T cells (Tregs) play a crucial role in mediating immune response. Yet an algorithmic understanding of the role of Tregs in adaptive immunity remains lacking. Here, we present a biophysically realistic model of Treg-mediated self-tolerance in which Tregs bind to self-antigens and locally i...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7817185/ https://ncbi.nlm.nih.gov/pubmed/33372155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011709118 |
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