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Near Miss or Standard of Care? DPYD Screening for Cancer Patients Receiving Fluorouracil
5-fluorouracil (5-FU) and its pro-drug capecitabine are widely used anticancer agents. Most 5-FU catabolism is dependent on dihydropyrimidine dehydrogenase (DPD) encoded by the DPYD gene, and DPYD variants that reduce DPD function increase 5-FU toxicity. Most DPD deficient patients are heterozygous...
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| 出版年: | Curr Oncol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7816174/ https://ncbi.nlm.nih.gov/pubmed/33704179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/curroncol28010012 |
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