Apoptosis, G1 Phase Stall, and Premature Differentiation Account for Low Chimeric Competence of Human and Rhesus Monkey Naive Pluripotent Stem Cells

After reprogramming to naive pluripotency, human pluripotent stem cells (PSCs) still exhibit very low ability to make interspecies chimeras. Whether this is because they are inherently devoid of the attributes of chimeric competency or because naive PSCs cannot colonize embryos from distant species...

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Bibliografske podrobnosti
izdano v:Stem Cell Reports
Main Authors: Aksoy, Irène, Rognard, Cloé, Moulin, Anaïs, Marcy, Guillaume, Masfaraud, Etienne, Wianny, Florence, Cortay, Véronique, Bellemin-Ménard, Angèle, Doerflinger, Nathalie, Dirheimer, Manon, Mayère, Chloé, Bourillot, Pierre-Yves, Lynch, Cian, Raineteau, Olivier, Joly, Thierry, Dehay, Colette, Serrano, Manuel, Afanassieff, Marielle, Savatier, Pierre
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815945/
https://ncbi.nlm.nih.gov/pubmed/33382978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.12.004
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