Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature. Here we show that, in early life, when the immune system develops, cDC2 exhibit a dual hematop...

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發表在:Nat Commun
Main Authors: Papaioannou, Nikos E., Salei, Natallia, Rambichler, Stephan, Ravi, Kaushikk, Popovic, Jelena, Küntzel, Vanessa, Lehmann, Christian H. K., Fiancette, Remi, Salvermoser, Johanna, Gajdasik, Dominika W., Mettler, Ramona, Messerer, Denise, Carrelha, Joana, Ohnmacht, Caspar, Haller, Dirk, Stumm, Ralf, Straub, Tobias, Jacobsen, Sten Eirik W., Schulz, Christian, Withers, David R., Schotta, Gunnar, Dudziak, Diana, Schraml, Barbara U.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815729/
https://ncbi.nlm.nih.gov/pubmed/33469015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20659-2
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