Multicentric carpotarsal osteolysis syndrome (MCTO) with generalized high bone turnover and high serum RANKL: Response to denosumab

MCTO is a rare disorder, caused by mutations in the MafB gene, a negative regulator of receptor activator of nuclear factor-кB ligand (RANKL). Manifestations include carpal and tarsal osteolysis and renal failure. Pathophysiology is poorly understood, and no effective treatment is available. In this...

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Библиографические подробности
Опубликовано в: :Bone Rep
Главные авторы: Regev, Ravit, Sochett, Etienne B., Elia, Yesmino, Laxer, Ronald M., Noone, Damien, Whitney-Mahoney, Kristi, Filipowski, Kornelia, Shamas, Amer, Vali, Reza
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2021
Предметы:
Case Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815641/
https://ncbi.nlm.nih.gov/pubmed/33506078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bonr.2021.100747
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