Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum

rIL-10 plays a major role in restricting exaggerated inflammatory and immune responses, thus preventing tissue damage. However, the restriction of inflammatory and immune responses by IL-10 can also favor the development and/or persistence of chronic infections or neoplasms. Dogs that succumb to can...

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Veröffentlicht in:PLoS One
Hauptverfasser: Santos, Catiule de Oliveira, Costa, Sidnei Ferro, Souza, Fabiana Santana, Mendes, Jessica Mariane Ferreira, de Pinheiro, Cristiane Garboggini Melo, Moreira, Diogo Rodrigo de Magalhães, Silva, Luciano Kalabric, de Lima, Valeria Marçal Felix, de Sá Oliveira, Geraldo Gileno
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815104/
https://ncbi.nlm.nih.gov/pubmed/33465107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239171
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