The Early Evolution of Oral Poliovirus Vaccine Is Shaped by Strong Positive Selection and Tight Transmission Bottlenecks

The emergence of circulating vaccine-derived polioviruses through evolution of the oral polio vaccine (OPV) poses a significant obstacle to polio eradication. Understanding the early genetic changes that occur as OPV evolves and transmits is important for preventing future outbreaks. Here, we use de...

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Vydáno v:Cell Host Microbe
Hlavní autoři: Valesano, Andrew L., Taniuchi, Mami, Fitzsimmons, William J., Islam, Md Ohedul, Ahmed, Tahmina, Zaman, Khalequ, Haque, Rashidul, Wong, Wesley, Famulare, Michael, Lauring, Adam S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815045/
https://ncbi.nlm.nih.gov/pubmed/33212020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.10.011
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