MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase

INTRODUCTION: Multiple myeloma (MM) remains an incurable disease, and patient survival requires a better understanding of this malignancy’s molecular aspects. Heparanase (HPSE) is highly expressed in aggressive MM cells and related to tumor growth, metastasis, and bortezomib (BTZ) resistance. Thus,...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Rodrigues-Junior, Dorival Mendes, Pelarin, Maria Fernanda de Andrade, Nader, Helena Bonciani, Vettore, André Luiz, Pinhal, Maria Aparecida Silva
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2021
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814994/
https://ncbi.nlm.nih.gov/pubmed/33488100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S286751
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