Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

BACKGROUND: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed. One approach in this regard a...

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Bibliografiske detaljer
Udgivet i:Biol Direct
Main Authors: Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Yang, Hongbin, Bender, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814730/
https://ncbi.nlm.nih.gov/pubmed/33461600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13062-020-00285-0
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