Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy

Painful neuropathy is a frequent complication in diabetes. Proopiomelanocortin (POMC) is an endogenous opioid precursor peptide, which plays a protective role against pain. Here, we report dysfunctional POMC-mediated antinociception in sensory neurons in diabetes. In streptozotocin-induced diabetic...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Deshpande, Divija, Agarwal, Nitin, Fleming, Thomas, Gaveriaux-Ruff, Claire, Klose, Christoph S. N., Tappe-Theodor, Anke, Kuner, Rohini, Nawroth, Peter
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814083/
https://ncbi.nlm.nih.gov/pubmed/33462216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20677-0
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