Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteo...

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Vydáno v:Nat Commun
Hlavní autoři: Garcia-Gomez, Antonio, Li, Tianlu, de la Calle-Fabregat, Carlos, Rodríguez-Ubreva, Javier, Ciudad, Laura, Català-Moll, Francesc, Godoy-Tena, Gerard, Martín-Sánchez, Montserrat, San-Segundo, Laura, Muntión, Sandra, Morales, Xabier, Ortiz-de-Solórzano, Carlos, Oyarzabal, Julen, San José-Enériz, Edurne, Esteller, Manel, Agirre, Xabier, Prosper, Felipe, Garayoa, Mercedes, Ballestar, Esteban
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813865/
https://ncbi.nlm.nih.gov/pubmed/33462210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20715-x
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