Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson’s disease

Wilson’s disease (WD) is an inherited disorder characterized by excessive accumulation of copper in the body, particularly in the liver and brain. In the central nervous system (CNS), extracellular copper accumulation triggers pathological microglial activation and subsequent neurotoxicity. Growing...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Dong, Jianjian, Wang, Xun, Xu, Chenchen, Gao, Manli, Wang, Shijing, Zhang, Jin, Tong, Haiyang, Wang, Lulu, Han, Yongzhu, Cheng, Nan, Han, Yongsheng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813851/
https://ncbi.nlm.nih.gov/pubmed/33462188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03397-1
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